The continuing improvement of early detection and screening measures, as well as advancements in treatments, coupled with a progressively aging population, has resulted in increased numbers of cancer survivors. This, in turn, has led to increased interest in and emphasis on assessing the health-related quality of life (HRQoL) o this population. Clinical trials and comparative effectiveness studies are being designed accordingly, including long-term follow-up to assess late effects of treatment and HRQoL in addition to the more traditional assessments of cancer outcomes, such as survival or other clinical parameters.

In light of this, we have proposed a Special Issue of Cancers dedicated to exploring the recent developments in HRQoL in the context of cancer survivorship. We welcome submissions focusing on clinical trials and other studies assessing long-term HRQoL trajectories; methodological papers, including both qualitative and quantitative research into HRQoL in cancer survivorship, are also of interest.